Graphene oxide gives a boost to new intranasal flu vaccine

Researchers at Georgia State University and Emory University have developed an intranasal influenza vaccine using recombinant hemagglutinin (HA), a protein found on the surface of influenza viruses, as the antigen component of the vaccine.

They also created a two-dimensional nanomaterial (polyethyleneimine-functionalized graphene oxide nanoparticles) and found that it displayed potent adjuvant (immunoenhancing) effects on influenza vaccines delivered intranasally.

In our study, we reported for the first time that two-dimensional graphene oxide nanomaterials had a potent adjuvant effect in boosting the immune responses of intranasal hemagglutinin (HA) vaccines, said Dr. Chunhong Dong, lead author of the study and a postdoctoral research Fellow in Dr. Baozhong Wang’s lab in the Institute for Biomedical Sciences.

This study gives new insights into developing high performance intranasal vaccine systems with two-dimensional sheet-like nanoparticles, Dong said. The graphene oxide nanoparticles have extraordinary attributes for drug delivery or vaccine development, such as the ultra-large surface area for high-density antigen loading, and the vaccine showed superior immunoenhancing properties in vitro and in vivo. The nanoplatform could be easily adapted for constructing mucosal vaccines for different respiratory pathogens.

The study, conducted in mice and cell culture, found the nanoparticles significantly enhanced immune responses at mucosal surfaces and throughout the body in mice. The robust immune responses conferred immune protection against influenza virus challenges by homologous (same) virus strains and heterologous (different) virus strains.

The results are also promising because needle-free, intranasal influenza vaccines possess superior logistical advantages over traditional injectable vaccines, such as easy administration with high acceptance for recipients and the avoidance of biohazardous waste.

Posted: May 04,2021 by Roni Peleg
I M Iventzilla (not verified)

There are plenty of studies lnking graphene to toxicity. I personally work with graphene and it caused an irritation reaction and permanent discoloration of my skin from a single exposure.Think what it might do to sensitive nasal mucosa.

Sun, 07/25/2021 - 18:16 Permalink
Do You O (not verified)

Here's a start:

Evaluation of pulmonary and systemic toxicity following lung exposure to graphite nanoplates: a member of the graphene-based nanomaterial family…

Toxicity of graphene-family nanoparticles: a general review of the origins and mechanisms…


Thu, 09/02/2021 - 00:37 Permalink
Craig (not verified)

see for the latest microscopy of the current "vaccines".

Moderna calls theirs and "operating Sytem." La Quinta Columna scientist group is confirming what Dr. Campra has found, is an english blog of theior findings and theories, lots of photos. Updated freuently.

Sat, 02/05/2022 - 08:58 Permalink
ROCKSTAR (not verified)

And there's your graphene nanotech "flu" shot, 5G QR code enabled of course, straight up your nose and through the Blood Brain Barrier no doubt >>>>>

Mon, 05/23/2022 - 02:52 Permalink